A Review: Novel Oral Lipid Based Formulation for Poorly Soluble Drugs

The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents a major challenge for the drug delivery. To over come this challenge, different methods were developed for the improvement of oral bioavailability, but some have major disadvantages. Recently, oral lipid based formulation is developed for the improvement of oral bioavailability. Lipid based formulation may improve oral bioavailability via several mechanisms; enhancement of gastrointestinal solubilisation remains argueably the most important method of absorption enhancement. This review discusses about lipid formulation, classification system (LFCS) based on different types of surfactants, like water-soluble and water-insoluble and different concentrations of the excipients those are generally recognized as safe (GRAS). Various parameters are mentioned for the evaluation of the lipid based formulation, like equilibrium phase behaviour, self dispersion and size dispersions, in vitro dispersion, droplet size and surface charge, in vitro release. In the USA, Japan and other countries, various poorly soluble drugs are commercially available as lipid-based formulations for oral administration.